study of antibiotic resistance of staph aureus and coagulase negative staphylococci isolated from patient samples

introduction: drug resistant staphylococci are the most important agents of nosocomial infections. in this survey, effect of different antibiotics on these bacteria and their drug resistance was investigated. methods: the study included 500 strains of staphylococci. minimum inhibitory concentrations of all antibiotics was determined by the broth macro dilution technique and standard methods from the national committee for clinical laboratory standards. result : oxacillin resistance of s. aureus was 14.2% and that of coagulase-negative staphylococci was 53.4%. the activity of different antibiotics is presented in detail. conclusion: surveillance of strains resistant to methicillin is necessary.